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Takashi Sugimura
is a Japanese biochemist, famous for research on chemical carcinogens. He received the Japan Prize for the contribution to establishment of fundamental concept on causes of cancer.〔(Dr. Takashi Sugimura 1997 (13th) Japan Prize Laureate )〕 He was elected as President of the Japan Academy on October 15, 2013.〔(日本学士院長の選定について Selection of President of the Japan Academy )〕
==Contribution==
Sugimura isolated and identified many mutagens with a structure of heterocyclic amine from foods cooked under ordinary conditions. He showed that tumors induced by these heterocyclic amines had genetic alterations. He further developed his studies to analyze multiple-step carcinogenesis at molecular levels to promote effective primary prevention of cancer.〔(Fellows of the AACR Academy )〕 His group identified the novel polymer poly(ADP-ribose) and demonstrated the presence of the enzyme poly ADP ribose polymerase (PARP). He also discovered the cognate catabolic enzyme, poly(ADP-ribose) glycohydrolase (PARG) and further elucidated the biology of poly(ADP-ribose). The astonishing discovery of pierisin, an apoptogenic peptide that ADP-ribosyaltes DNA, profoundly illuminates his scientific character and curiosity as well.
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